Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a significant...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes Mellitus: Introduction01:26

Diabetes Mellitus: Introduction

Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and long-term...
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Red bone marrow hosts metabolically active anucleate adipocytes that support hematopoiesis.

Cell reports·2026
Same author

Metabolic state determines the brain and direct islet effects of liraglutide on enhanced insulin secretion.

Diabetologia·2026
Same author

Extracellular matrix remodeling as a unique mechanism of expansion of periprostatic adipose tissue: implication for prostate cancer aggressiveness.

The Journal of pathology·2026
Same author

Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice.

Cell metabolism·2026
Same author

Zebrafish genetic model of neuromuscular degeneration associated with Atrogin-1 expression.

PLoS genetics·2026
Same author

Porphyromonas gingivalis-induced glucose intolerance during periapical lesions requires its LPS throught a Th17 immune response.

International journal of oral science·2025

Related Experiment Video

Updated: May 31, 2026

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
08:47

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

Apelin, diabetes, and obesity.

Isabelle Castan-Laurell1, Cédric Dray, Camille Attané

  • 1UMR 1048 INSERM, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC)/Université Paul Sabatier, 1 Ave J. Poulhès, BP 84225, 31432, Toulouse Cedex 4, France. isabelle.castan@inserm.fr

Endocrine
|July 5, 2011
PubMed
Summary

Apelin, an adipokine, plays a role in metabolic disorders like obesity and type 2 diabetes. Research suggests apelin has beneficial anti-obesity and anti-diabetic properties, making it a potential therapeutic target.

More Related Videos

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
09:20

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

Related Experiment Videos

Last Updated: May 31, 2026

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
08:47

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
09:20

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

Area of Science:

  • Endocrinology
  • Metabolic Research
  • Molecular Biology

Background:

  • Apelin is a peptide hormone and the endogenous ligand for the G-protein-coupled receptor APJ.
  • Both apelin and APJ are expressed in the central nervous system and peripheral tissues, including adipose tissue.
  • Apelin is recognized as an adipokine due to its production and secretion by adipocytes.

Purpose of the Study:

  • To review the link between apelin and metabolic disorders, focusing on obesity and type 2 diabetes.
  • To explore the role of apelin in glucose and lipid metabolism.
  • To evaluate apelin as a potential therapeutic target for metabolic diseases.

Main Methods:

  • Literature review of studies investigating apelin in metabolic disorders.
  • Analysis of research on apelin's involvement in glucose and lipid metabolism.
  • Examination of signaling pathways associated with apelin's metabolic effects.

Main Results:

  • Plasma apelin concentrations are reportedly increased in various metabolic pathologies, though findings are not universal.
  • Apelin significantly influences both glucose and lipid metabolism.
  • Apelin exhibits anti-obesity and anti-diabetic effects.

Conclusions:

  • Apelin is a key adipokine implicated in metabolic regulation.
  • Apelin demonstrates therapeutic potential for treating obesity and type 2 diabetes.
  • Targeting the apelin system offers a promising strategy for metabolic disorder management.