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Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
Published on: August 25, 2022
Neuroglobin expression in human arteriovenous malformation and intracerebral hemorrhage
Kunlin Jin1, XiaoOu Mao, Lin Xie
1Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA.
Abstract:
We reported previously that Notch signaling is activated in human arteriovenous malformations (AVMs) and that intracerebral hemorrhage (ICH) in humans is accompanied by increased neurogenesis. The former phenomenon may be involved in AVM pathogenesis and the latter in the brain's response to ICH-induced injury. Here we describe increased expression of the hypoxia-inducible neuroprotective protein, neuroglobin (Ngb), in neurons surrounding unruptured AVMs and in the perihematomal region adjacent to ICH. In these disorders, as in other clinical settings, such as ischemic stroke, AVM- and ICH-induced overexpression of Ngb may be stimulated by ischemic hypoxia and may help to constrain brain injury.
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