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Updated: May 31, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Diagnosis and treatment of hemorrhagic pituitary adenomas
Gang Huo1, Qing-Lin Feng, Mao-Yuan Tang
1Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China. xiaomin198171@tom.com
Insights
Magnetic resonance imaging (MRI) is superior to computed tomography (CT) for diagnosing hemorrhagic pituitary adenomas. Early surgical decompression, preferably via transsphenoidal microsurgery, offers optimal treatment outcomes.
Area of Science:
- Neurosurgery
- Radiology
- Endocrinology
Background:
- Hemorrhagic pituitary adenomas present diagnostic and therapeutic challenges.
- Timely diagnosis and intervention are crucial for patient outcomes.
Purpose of the Study:
- To evaluate the diagnostic accuracy of imaging modalities for hemorrhagic pituitary adenomas.
- To assess the effectiveness of surgical interventions for this condition.
Main Methods:
- Retrospective analysis of 72 patients with hemorrhagic pituitary adenoma.
- Comparison of computed tomography (CT) and magnetic resonance imaging (MRI) diagnostic rates.
- Review of surgical approaches including transsphenoidal and transfrontal operations.
- Assessment of resection types: total, subtotal, and partial.
Main Results:
- MRI demonstrated a higher positive rate (94.44%) compared to CT (55.17%).
- All surgical procedures relieved headaches and vomiting; improved consciousness and vision were observed.
- Post-operative follow-up showed 14 cures, 32 alleviated symptoms, and 6 relapses among 56 patients.
Conclusions:
- MRI is superior to CT for diagnosing hemorrhagic pituitary adenomas.
- Prompt surgical decompression is recommended.
- Transsphenoidal microsurgery is the preferred optimal treatment approach.
Abstract:
We retrospectively analyzed the clinical manifestations, imaging results, and surgical treatment conditions of 72 patients who were diagnosed with hemorrhagic pituitary adenoma between January 2006 and May 2009 at our Department of Neurosurgery. We reached the conclusion that the CT-positive rate was 55.17% and the MRI-positive rate was 94.44%. Sixty-six patients underwent transsphenoidal operations; 6 patients, transfrontal operations; 52, total resections; 10, subtotal resections; and 10, partial resections. All procedures alleviated patients' headaches and stopped vomiting; patients with impaired consciousness gradually became clear-headed after the operations; patients whose preoperative eyesight had been impaired improved to different degrees, and ophthalmoplegia improved. Fifty-six patients were followed, 14 were cured, 32 had alleviated symptoms but 4 did not, and 6 relapsed. Our finding suggests that MRI scanning is superior to CT scanning in the diagnosis of hemorrhagic pituitary adenomas. Surgical decompression should be performed as soon as possible, and transsphenoidal microsurgery is the optimal treatment.
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