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Role of ADARs in mouse development.

Carl R Walkley1, Brian Liddicoat, Jochen C Hartner

  • 1St. Vincent's Institute of Medical Research and Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, VIC 3065, Australia.

Current Topics in Microbiology and Immunology
|July 5, 2011
PubMed
Summary
This summary is machine-generated.

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Adenosine to inosine (A-to-I) RNA editing, mediated by ADAR enzymes, regulates gene expression. Studies using gene-targeted mice reveal crucial roles for ADARs in mammalian development, particularly in neuronal and hematopoietic tissues.

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • Adenosine to inosine (A-to-I) editing is a critical posttranscriptional RNA modification.
  • This process is catalyzed by adenosine deaminases acting on RNA (ADAR) enzymes.
  • ADAR efficiency is influenced by RNA substrate structure.

Purpose of the Study:

  • To investigate the biological functions of mammalian ADARs.
  • To understand the roles of ADARs in embryonic and postnatal development.

Main Methods:

  • Creation and analysis of gene-targeted mice with modified ADAR alleles.
  • Studying the effects of disrupted ADAR function in vivo.

Main Results:

  • Significant progress has been made in understanding mammalian ADAR functions.

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  • ADARs play vital roles in neuronal tissue development.
  • ADARs are also important in hematopoietic tissue during development.

    • Conclusions:

    • ADAR-mediated RNA editing is essential for normal mammalian development.
    • Disruption of ADAR function has significant consequences for tissue development.
    • Further research on ADARs can elucidate complex gene regulation mechanisms.