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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

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Interference with p53 functions in human viral infections, a target for novel antiviral strategies?

Pedro A Lazo1, Claudio R Santos

  • 1Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC) - Universidad de Salamanca, Salamanca, Spain. pedro.lazo@usal.es.

Reviews in Medical Virology
|July 5, 2011
PubMed

Insights

Viruses manipulate host cell p53 pathways to replicate. Restoring p53 function could be a novel therapeutic strategy to combat viral infections and pathogenesis.

Area of Science:

  • Virology
  • Molecular Biology
  • Cellular Biology

Background:

  • Viral infections induce cellular stress responses.
  • The p53 protein regulates cell cycle and apoptosis, crucial for host defense against pathogens.
  • Viruses have evolved mechanisms to evade or subvert p53-mediated antiviral activities.

Purpose of the Study:

  • To review how viral proteins interfere with p53 pathways.
  • To explore the potential of p53 reactivation as an antiviral therapy.

Main Methods:

  • Literature review of viral manipulation of p53.
  • Analysis of viral protein interactions with p53 and its regulators (Hdm2, Akt).
  • Discussion of interferon-mediated pathways affecting p53.

Main Results:

  • Viruses employ direct and indirect strategies to inhibit p53 function.
  • Viral interference with p53 is a key aspect of viral pathogenesis.
  • Oncological p53 reactivation strategies may be applicable to viral infections.

Conclusions:

  • Viral manipulation of p53 is essential for viral replication and pathogenesis.
  • Pharmacological rescue of p53 function presents a promising therapeutic avenue for controlling viral infections.
  • Targeting p53 could limit viral spread and disease progression.

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