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Updated: May 31, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
Regulatory T helper cells in pregnancy and their roles in systemic versus local immune tolerance
Jan Ernerudh1, Göran Berg, Jenny Mjösberg
1Division of Clinical Immunology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden. jan.ernerudh@lio.se
Problem:
During pregnancy, the maternal immune system needs to adapt in order not to reject the semi-allogenic fetus.
Method:
In this review, we describe and discuss the role of regulatory T (Treg) cells in fetal tolerance.
Results:
Treg cells constitute a T helper lineage that is derived from thymus (natural Treg cells) or is induced in the periphery (induced Treg cells). Treg cells are enriched at the fetal-maternal interface, showing a suppressive phenotype. In contrast, Treg cells are not increased in the circulation of pregnant women, and the suppressive capacity is similar to that in non-pregnant women. However, aberrations in Treg frequencies and functions, both systemically and in the uterus, may be involved in the complications of pregnancy.
Conclusion:
Treg cells seem to have distinguished roles locally versus systemically, based on their distribution and phenotype.
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