Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Increased Intracranial Pressure l: Introduction01:14

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neurosurgical Endovascular Credentialing in Europe and the United Kingdom for the "Complete" Neurovascular Surgeon: The Time has Come.

Neurosurgery·2026
Same author

Outcome predictors in older adults (≥ 65 years) with aneurysmal subarachnoid haemorrhage.

Neurosurgical review·2026
Same author

Early analysis of data from the British & Irish Brain Arteriovenous Malformations Registry (BIBAR).

Brain & spine·2025
Same author

Core Outcome Sets for Meningioma In Clinical studies (COSMIC): An international patient and healthcare professional consensus for research studies.

Neuro-oncology practice·2025
Same author

Preliminary Experience with the use of a 3-Dimensional Exoscope for Excision of Unruptured Brain Arteriovenous Malformations: Case Series and Comparative Analysis.

World neurosurgery·2025
Same author

Intra-operative neurophysiological monitoring as an adjunct to resection of eloquent cerebral arteriovenous malformations: a retrospective cohort study.

British journal of neurosurgery·2025

Related Experiment Video

Updated: May 31, 2026

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
10:34

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

Subarachnoid haemorrhage (spontaneous aneurysmal).

Mohsen Javadpour1, Nicholas Silver

  • 1Department of Neurosurgery, Walton Centre for Neurology and Neurosurgery, Liverpool University, Liverpool, UK.

BMJ Clinical Evidence
|July 6, 2011
PubMed
Summary

This systematic review evaluates surgical and medical treatments for aneurysmal subarachnoid haemorrhage (SAH). It assesses interventions like coiling, clipping, and nimodipine for effectiveness and safety in SAH patients.

Area of Science:

  • Neurology
  • Neurosurgery
  • Critical Care Medicine

Background:

  • Subarachnoid haemorrhage (SAH) is a critical neurological condition, often caused by ruptured aneurysms, presenting with severe headache.
  • Spontaneous SAH constitutes approximately 5% of all stroke cases, with aneurysms responsible for 85% of spontaneous instances.
  • Diagnosis requires high clinical suspicion due to variable presentations, including insidious headache onset or absence of headache.

Purpose of the Study:

  • To systematically review the effects of surgical treatments for confirmed aneurysmal subarachnoid haemorrhage.
  • To evaluate the efficacy of medical treatments for preventing delayed cerebral ischemia in patients with aneurysmal subarachnoid haemorrhage.

Main Methods:

  • Systematic review methodology was employed, searching major databases up to March 2009.

More Related Videos

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

Endovascular Perforation Model for Subarachnoid Hemorrhage Combined with Magnetic Resonance Imaging (MRI)
06:30

Endovascular Perforation Model for Subarachnoid Hemorrhage Combined with Magnetic Resonance Imaging (MRI)

Published on: December 16, 2021

Related Experiment Videos

Last Updated: May 31, 2026

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
10:34

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

Endovascular Perforation Model for Subarachnoid Hemorrhage Combined with Magnetic Resonance Imaging (MRI)
06:30

Endovascular Perforation Model for Subarachnoid Hemorrhage Combined with Magnetic Resonance Imaging (MRI)

Published on: December 16, 2021

  • Inclusion criteria encompassed systematic reviews, randomized controlled trials (RCTs), and observational studies.
  • Harms alerts from regulatory agencies like the FDA and MHRA were also incorporated.

    • Main Results:

    • Six systematic reviews, RCTs, or observational studies met the inclusion criteria for the review.
    • A GRADE evaluation was conducted to assess the quality of evidence for the interventions studied.

    Conclusions:

    • The review synthesizes evidence on the effectiveness and safety of endovascular coiling and surgical clipping for aneurysmal SAH.
    • Information on the optimal timing of surgery and the use of oral and intravenous nimodipine for preventing delayed cerebral ischemia is presented.