Inhibitory effect of local anesthetics on Na+/H+ antiporter in brush border membrane-reconstituted vesicles
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S Shibamoto1, T Hori, M Hayakawa
1Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, Japan.
Life Sciences
|January 1, 1990
Abstract:
The effects of three local anesthetics, lidocaine, dibucaine, and tetracaine, on Na+/H+ antiporter activity were examined in brush border membrane-reconstituted vesicles. Lidocaine at 10 microM inhibited H+ efflux in the presence of an inward Na+ gradient, suggesting that this anesthetic specifically inhibits the Na+/H+ antiporter. On the other hand, dibucaine and tetracaine decreased H+ efflux even in the absence of a Na+ gradient.