Related Experiment Video
Updated: May 31, 2026
05:30
Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer
Published on: October 31, 2025
[Node negative breast cancer. Beyond international consensus: a pragmatic approach]
Frédérique Penault-Llorca1, David Coeffic, Thierry Delozier
1Centre Jean-Perrin, service de pathologie, 58, rue Montalembert BP 392, 63011 Clermont-Ferrand, France. fpenault@cjp.fr
Bulletin Du Cancer
|July 6, 2011
Summary
Early breast cancer management is shifting due to screening and guidelines, creating a paradox. Adjuvant chemotherapy strategies need re-evaluation for the increasing node-negative population.
Area of Science:
- Oncology
- Clinical Practice
- Epidemiology
Background:
- Early breast cancer management practices have evolved.
- Key organizational changes include mass screening and guideline development.
- Screening alters breast cancer presentation and epidemiology.
Framework:
- Adjuvant treatment guidelines aim for evidence-based patient management.
- Clinical studies often focus on node-positive populations.
- A growing node-negative population presents unique challenges.
Implementation:
- Daily practice faces a paradoxical situation with node-negative majority.
- Discrepancies exist between various clinical guidelines.
- Oncologists require clearer directions for adjuvant chemotherapy.
Implications:
- Re-evaluation of adjuvant chemotherapy is necessary for node-negative patients.
- Addressing guideline discrepancies is crucial for consistent care.
- Future research should focus on optimizing treatment for early-stage breast cancer.
Related Concept Videos
02:56Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:56Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:59Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
01:27Nursing Ethical Principles II
Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's cancer...
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's cancer...
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...