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iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

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Updated: May 31, 2026

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Published on: November 18, 2022

Using stem cells to study and possibly treat type 1 diabetes.

¹Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA. dmelton@harvard.edu

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences

|July 6, 2011

Summary

This summary is machine-generated.

Stem cell therapies offer potential for type 1 diabetes by replacing damaged cells. Researchers are also using stem cell derivatives to develop new drugs for degenerative diseases.

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Area of Science:

* Regenerative Medicine
* Developmental Biology
* Endocrinology

Background:

* Stem cells possess pluripotency, enabling differentiation into diverse cell types.
* Stem cell derivatives are valuable tools for drug screening in degenerative diseases.
* Type 1 diabetes involves the autoimmune destruction of insulin-producing beta cells.

Purpose of the Study:

* To explore the application of stem cells in type 1 diabetes treatment.
* To review the use of stem cell derivatives in drug discovery for diabetes.
* To identify current successes and future challenges in stem cell-based diabetes therapies.

Main Methods:

* Review of current scientific literature on stem cell applications in diabetes.
* Analysis of preclinical and clinical studies involving stem cell therapies.
* Examination of drug screening platforms utilizing stem cell-derived models.

Main Results:

* Demonstrated success in preclinical models using stem cell-derived beta cells.
* Identified specific drug candidates showing promise in correcting diabetes phenotypes.
* Highlighted challenges including immune rejection and long-term cell survival.

Conclusions:

* Stem cell-based approaches hold significant promise for type 1 diabetes treatment and drug development.
* Overcoming technical hurdles is crucial for translating research into clinical therapies.
* Continued research is essential for advancing stem cell applications in regenerative medicine.