Related Experiment Video
Updated: May 31, 2026

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
Population-based proband-oriented pedigree information system: application to hypertension with population-based
Sherry Yueh-Hsia Chiu1, Li-Sheng Chen, Amy Ming-Fang Yen
1Department and Graduate Institute of Health Care Management, College of Management, Chang Gung University, Tao-Yuan, Taiwan.
Objective:
To develop a population-based proband-oriented pedigree information system that can be easily applied to various diseases in genetic epidemiological studies, making allowance for the capture of theoretical family relationships. DESIGNS AND MEASUREMENTS: A population-based proband-oriented pedigree information system with ties of consanguinity based on both population-based household registry data and Keelung Community Integrated Screening data was proposed to build a comprehensive extended family pedigree structure to accommodate a series of genetic studies on different diseases. We also developed an algorithm to efficiently assess how well theoretical family relationships affecting the occurrence of diseases across three generations with respect to the relative relationship score, a quantitative indicator of genetic influence, were captured.
Results:
We applied this population-based proband-oriented pedigree information system to estimate the rate of hypertension with various relative relationships given the selection of probands. The degree of capturing complete familial relationships was assessed for three generations. The risk for early onset of hypertension was proportional to the proband-oriented relative relationship score with 2% increased risk and 1% correction for incomplete capture.
Conclusions:
The population-based proband-oriented pedigree information system is powerful and can support various genetic descriptive and analytic epidemiological studies.
Related Concept Videos
Errors occurring during blood pressure monitoring
Several factors...
Analysis of Population Pharmacokinetic Data
Pre-Procedural Guidelines for Assessing Blood Pressure
Pedigree Analysis
Pedigree Analysis
Hypertension III: Clinical Manifestations and Diagnostic Studies