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Updated: May 31, 2026

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography
Published on: October 25, 2018
Self-aligned immobilization of proteins utilizing PEG patterns
Lap Man Lee1, Ronald L Heimark, James C Baygents
1Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, AZ 85719, USA.
Abstract:
A novel self-aligned method to selectively immobilize proteins on a silicon dioxide surface is developed in conjunction with a standard lift-off patterning technique of a PEG layer. The approach is designed to photolithographically pattern regions that specifically bind target proteins and particles, surrounded by regions that suppress non-specific attachment of bio-species. The physical and biological properties of the derivatized surfaces at the end of the fabrication process are characterized.
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