Related Experiment Video
Updated: May 31, 2026

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting
Published on: June 18, 2018
Bone marrow stem cell mobilization in stroke: a 'bonehead' may be good after all!
1Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA. cborlong@health.usf.edu
Mobilizing bone marrow (BM)-derived cells to the brain shows promise for stroke recovery. This
Area of Science:
- Regenerative Medicine
- Neuroscience
- Stem Cell Biology
Background:
- Mobilizing bone marrow (BM)-derived cells to the brain is a key area in regenerative medicine.
- Evidence shows these cells can migrate from BM to peripheral blood and then to injured brain tissue.
- This process is observed in BM stem cell mobilization after ischemic brain injury.
Purpose of the Study:
- To review laboratory studies on the therapeutic mobilization of transplanted BM stem cells for brain repair.
- To explore the role of these cells in promoting brain plasticity and remodeling following stroke.
Main Methods:
- Review of accumulating laboratory studies.
- Analysis of evidence for BM stem cell mobilization and homing to the brain.
- Focus on studies related to stroke and ischemic brain injury.
Main Results:
- Accumulating laboratory evidence implicates BM-derived cells in brain repair mechanisms.
- Therapeutic mobilization of transplanted BM stem cells shows potential for stroke recovery.
- These cells contribute to brain plasticity and remodeling after injury.
Conclusions:
- Mobilizing bone marrow stem cells is a viable therapeutic strategy for stroke.
- Further research into this 'bonehead' approach could advance regenerative medicine for neurological disorders.
More Related Videos
03:40Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
Published on: December 8, 2023
10:03Tracking Superparamagnetic Iron Oxide-labeled Mesenchymal Stem Cells using MRI after Intranasal Delivery in a Traumatic Brain Injury Murine Model
Published on: November 21, 2019
Related Concept Videos
Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Multipotency of Hematopoietic Stem Cells
Hematopoiesis