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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

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Correlation between peripheral arterial disease and stage of chronic kidney disease

Phuangpaka Ungprasert1, Suwatchai Pornratanarangsi

  • 1Division of Cardiology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|July 6, 2011
PubMed

Insights

The prevalence of asymptomatic peripheral arterial disease (PAD) increases with chronic kidney disease (CKD) stage. This study used ankle-brachial index (ABI) to assess PAD in CKD patients.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Vascular Medicine

Background:

  • Atherosclerotic disease is a leading cause of morbidity.
  • Chronic kidney disease (CKD) is a known risk factor for cardiovascular disease.
  • The relationship between peripheral arterial disease (PAD) and CKD stages requires further investigation.

Purpose of the Study:

  • To determine the prevalence of asymptomatic PAD in patients across different stages of CKD.
  • To utilize ankle-brachial index (ABI) measurements for PAD detection.

Main Methods:

  • A study involving 201 patients with CKD, classified by K/DOQI stages.
  • Exclusion of patients with symptomatic PAD.
  • Diagnosis of PAD using ABI measurement (ABI < 0.9).

Main Results:

  • 22.4% of patients had an ABI < 0.9, associated with older age, female sex, and lower diastolic blood pressure.
  • Asymptomatic PAD prevalence and severity (lower mean ABI) increased with advanced CKD stages (Stage 4 and 5 vs. Stage 1 and 2).
  • Diabetes and coronary artery disease were more common in patients with abnormal ABI, though not statistically significant.

Conclusions:

  • Asymptomatic PAD prevalence significantly rises with the progression of CKD.
  • Early detection and management of PAD in CKD patients are crucial.
Abstract

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