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Deformation of Member under Multiple Loadings

Deformation of Member under Multiple Loadings

When a rod is made of different materials or has various cross-sections, it must be divided into parts that meet the necessary conditions for determining the deformation. These parts are each characterized by their internal force, cross-sectional area, length, and modulus of elasticity. These parameters are then used to compute the deformation of the entire rod.
In the case of a member with a variable cross-section, the strain is not constant but depends on the position. The deformation of an...

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Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow

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Separation of deformable particles in deterministic lateral displacement devices.

Raymond Quek¹, Duc Vinh Le, K-H Chiam

¹A*STAR Institute of High Performance Computing, 1 Fusionopolis Way #16-16, Singapore 138632, Singapore.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics

|July 7, 2011

Summary

Numerical simulations reveal a third "dispersive" trajectory for large, rigid particles in deterministic lateral displacement devices. This behavior, unlike zigzag or lateral displacement, hinders particle separation and sorting capabilities.

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Last Updated: May 31, 2026

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Spatial Separation of Molecular Conformers and Clusters

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Published on: January 9, 2014

Area of Science:

Biophysics
Microfluidics
Computational Science

Background:

Deterministic lateral displacement (DLD) devices, or bump arrays, are used for particle separation.
These devices feature rows of micropillars with shifted arrangements.

Purpose of the Study:

To investigate particle trajectories in DLD devices using numerical simulations.
To identify and characterize novel particle behaviors beyond experimentally observed ones.

Main Methods:

Numerical simulations of deformable bodies (capsules, vesicles, cells) in DLD devices.
Analysis of particle trajectories based on parameters like row shift, row separation, particle diameter, and deformability.

Main Results:

Identification of a third trajectory type: 'dispersive', characterized by random-like interactions.
Dispersive trajectories occur for large, rigid particles (diameter > half gap, stiffness > 500 MPa).
Mapping of phase space reveals transitions between zigzag, lateral displacement, and dispersive trajectories.

Conclusions:

Dispersive trajectories present a challenge for particle sorting in DLD devices.
Understanding these trajectories is crucial for optimizing DLD device design and prototyping.
Numerical simulations provide valuable insights for improving microfluidic separation technologies.