Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Bone Remodeling and Repair

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Developmental Neurotoxicity of Short-Chain Phthalates in Human Neurospheres.

Environmental toxicology and pharmacology·2026

Same author

Lymph node-targeted mRNA delivery of fine-tuned peptide-nanocomplexes for SARS-CoV-2 Vaccination.

Biomaterials·2026

Same author

Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease.

The New England journal of medicine·2026

Same author

A Multifunctional β-Defensin-3 Mimetic Peptide Modulates Host-Biofilm Interactions and Reduces Bone Loss in Periodontitis.

Journal of periodontal research·2026

Same author

Time-dependent biphasic alterations in brain metabolism following chronic ketamine exposure in mice.

Frontiers in pharmacology·2025

Same author

ACLY facilitates alanine flux in the livers of db/db mice: a hyperpolarized [1-13C]pyruvate MRS study.

Frontiers in endocrinology·2025

Search research articles

Related Experiment Video

Updated: May 31, 2026

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Bioactive peptide-modified biomaterials for bone regeneration.

Jue-Yeon Lee¹, Young-Suk Choi, Seung-Jin Lee

¹Research Center, Nano Intelligent Biomedical Engineering Corporation, College of Dentistry, Seoul National University, 28-22 Yongon-Dong, Chongno-Ku, Seoul 110-749, South Korea.

Current Pharmaceutical Design

|July 7, 2011

Summary

Bioactive peptides enhance tissue engineering scaffolds by mimicking the extracellular matrix. These peptides improve cell attachment and function, offering advantages over growth factors for regenerative medicine.

More Related Videos

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

Related Experiment Videos

Last Updated: May 31, 2026

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Bioactive biomaterials are crucial for tissue engineering scaffolds, mimicking the natural extracellular matrix.
Incorporating synthetic short peptide sequences into materials enhances cell attachment and function.
Peptides offer advantages over growth factors, including reduced immunogenicity and fewer side effects.

Purpose of the Study:

To review the use of bioactive peptides in tissue engineering scaffolds.
To discuss peptides for cell binding, biomineralization, and receptor binding in bone regeneration.
To address peptide immobilization and potential complications.

Main Methods:

Review of literature on bioactive peptides and biomaterial scaffolds.
Discussion of peptide incorporation strategies (surface modification, bulk incorporation).
Summary of self-assembled peptide amphiphiles for scaffold development.

Main Results:

Peptide-modified scaffolds promote cell attachment, proliferation, and differentiation.
Specific peptides are effective for bone regeneration (cell-binding, biomineralization, receptor-binding).
Self-assembled peptide amphiphiles offer new possibilities for 3D scaffold fabrication.

Conclusions:

Bioactive peptides are versatile tools for designing advanced tissue engineering scaffolds.
Peptide incorporation strategies and immobilization are key considerations for efficacy.
Further development of peptide-based scaffolds holds significant promise for regenerative therapies.