Related Experiment Video
Updated: May 31, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
Effect of cholesterol and CYP46 polymorphism on cognitive event-related potentials
Chiou-Lian Lai1, Chung-Yao Hsu1, Li-Min Liou1
1Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, TaiwanDepartment of Neurology, Kaohsiung Medical University Hospital Kaohsiung, TaiwanDepartment of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, TaiwanDepartment of Guidance and Counseling, National Changhua University of Education, Taiwan.
Abstract:
The integrated effect of the cholesterol and CYP46 genotypes on the risk of cognitive decline needs to be determined. Using the Cognitive Abilities Screening Instrument (CASI), 145 mentally healthy middle-aged and older adults were recruited to investigate the influence of cholesterol and CYP46 genotypes on cognitive event-related potentials (ERPs). The subjects with a high low-density lipoprotein cholesterol (LDL-C) level displayed significantly lower amplitude ERPs, although the CASI scores showed no difference. There was no association between the CYP46 genotypes, CASI scores, cholesterol levels, and measures of ERPs. No interaction between LDL-C level and CYP46 genotypes was noted. The LDL-C level is an independent predictor of low P300 amplitude. Prevention and treatment of high cholesterol may be of potential benefit in reducing cognitive impairment.
Related Concept Videos
Pharmacogenetics of Phase I Enzymes: Cytochrome P450 Isozymes
Language and Cognition
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Cognitivism
Previously dominated by behaviorism, which prioritized observable behaviors and largely ignored mental processes, psychology transformed in the 1950s. Cognitive psychologists argue that understanding how we think and process information is...
