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Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...

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Related Experiment Video

Updated: May 31, 2026

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
10:04

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Published on: October 20, 2017

Amyloid imaging.

Victor L Villemagne1, Christopher C Rowe

  • 1Department of Nuclear Medicine and Centre for PET, Austin Health, Victoria, Australia. villemagne@petnm.unimelb.edu.au

International Psychogeriatrics
|July 7, 2011
PubMed
Summary
This summary is machine-generated.

Positron emission tomography (PET) scans reveal higher beta-amyloid (Aβ) in Alzheimer's disease (AD) patients, aiding early diagnosis. This amyloid imaging is crucial for tracking disease progression and developing new therapies.

Related Experiment Videos

Last Updated: May 31, 2026

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
10:04

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Published on: October 20, 2017

Area of Science:

  • Neuroscience
  • Radiology
  • Gerontology

Background:

  • Molecular neuroimaging, particularly Positron Emission Tomography (PET), is increasingly vital for early and differential diagnosis of Alzheimer's disease (AD).
  • The development of novel therapeutic strategies targeting brain beta-amyloid (Aβ) burden necessitates in vivo assessment methods.
  • Amyloid PET imaging has demonstrated higher Aβ burden in AD patients compared to healthy controls and frontotemporal dementia patients.

Purpose of the Study:

  • To evaluate the utility of amyloid imaging with PET in the diagnosis and understanding of Alzheimer's disease.
  • To assess the relationship between Aβ burden, cognitive decline, and aging.
  • To explore the potential of amyloid imaging in identifying preclinical and prodromal AD.

Main Methods:

  • Utilizing PET imaging to quantify Aβ burden in the gray matter of various patient groups and healthy controls.
  • Comparing Aβ burden in ApoE ε4 carriers versus non-carriers.
  • Correlating amyloid imaging findings with histopathological reports and FDG-PET sensitivity.

Main Results:

  • Amyloid PET imaging shows significantly higher Aβ burden in AD patients' gray matter.
  • ApoE ε4 carriers exhibit higher Aβ burden irrespective of diagnosis or disease severity.
  • Amyloid imaging aligns with histopathology and is more sensitive for AD diagnosis than FDG-PET.
  • Prevalence of amyloid-positive scans increases with age in healthy older adults (20% in 7th decade to 60% in 9th).
  • 40-60% of individuals with mild cognitive impairment (MCI) show detectable Aβ deposition.
  • Aβ deposition in healthy older adults and MCI is linked to increased risk of cognitive decline and AD dementia.

Conclusions:

  • Amyloid imaging with PET is a valuable tool for discriminating dementias and diagnosing AD.
  • Aβ deposition is not a normal aspect of aging and appears to precede cognitive symptoms, indicating preclinical or prodromal AD.
  • Further longitudinal studies with advanced tracers are needed to confirm the role of Aβ in AD pathogenesis.