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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
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Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...

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Related Experiment Video

Updated: May 31, 2026

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)
10:02

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

Published on: May 2, 2012

Perfusion SPECT and FDG-PET.

Karl Herholz1

  • 1Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK. karl.herholz@manchester.ac.uk

International Psychogeriatrics
|July 7, 2011
PubMed
Summary
This summary is machine-generated.

Fluorodeoxyglucose positron emission tomography (FDG-PET) imaging reveals characteristic brain activity patterns in Alzheimer's disease (AD). This functional biomarker aids in early diagnosis and monitoring of neurodegenerative dementias.

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Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

Area of Science:

  • Neuroimaging
  • Neurology
  • Nuclear Medicine

Background:

  • Alzheimer's disease (AD) exhibits distinct patterns of regional neuronal activity impairment, primarily affecting temporo-parietal and mesial temporal cortices.
  • Functional neuroimaging techniques like perfusion SPECT and FDG-PET reflect neuronal activity and can serve as biomarkers for AD diagnosis and progression monitoring.

Purpose of the Study:

  • To evaluate the role of FDG-PET as a diagnostic and monitoring biomarker for Alzheimer's disease and other neurodegenerative dementias.
  • To compare the utility of FDG-PET with perfusion SPECT for assessing regional functional impairment.

Main Methods:

  • Analysis of functional neuroimaging data (perfusion SPECT and FDG-PET) to identify characteristic patterns of reduced neuronal activity in Alzheimer's disease.
  • Correlation of imaging findings with clinical symptoms and disease progression in patients with mild cognitive impairment and dementia.

Main Results:

  • FDG-PET demonstrates quantitative accuracy superior to perfusion SPECT, making it more suitable for multicenter studies.
  • Observed regional metabolic and blood flow changes in FDG-PET correlate with clinical symptoms and are often associated with cortical atrophy.
  • FDG-PET complements amyloid PET by reflecting current neuronal function rather than molecular markers without direct symptom correlation.

Conclusions:

  • FDG-PET serves as a valuable biomarker for diagnosing Alzheimer's disease and other dementias at the mild cognitive impairment stage and for tracking disease progression.
  • Increasing availability and standardization of FDG-PET, coupled with training initiatives, position it for expanded use in early AD diagnosis and clinical trials.
  • FDG-PET is expected to play a crucial role in identifying patients for early intervention and in evaluating novel dementia therapies.