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Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

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Published on: July 10, 2018

Systemic inflammation impairs respiratory chemoreflexes and plasticity.

A G Huxtable¹, S Vinit, J A Windelborn

¹Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, United States.

Respiratory Physiology & Neurobiology

|July 7, 2011

Summary

Systemic inflammation impairs ventilatory control by affecting chemoreflexes and respiratory motor plasticity. Understanding these mechanisms is crucial for treating breathing disorders like spinal cord injury.

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Area of Science:

Neuroscience
Physiology
Respiratory Medicine

Background:

Adequate breathing relies on effective ventilatory control, essential for compensating for lung and central nervous system disorders.
Systemic and neuroinflammation are common in these disorders, yet their impact on ventilatory control mechanisms remains poorly understood.

Purpose of the Study:

To review evidence and present new data on how inflammation affects ventilatory control.
To investigate the impact of inflammation on chemoreflexes and respiratory motor plasticity.

Main Methods:

Review of existing literature on inflammation and ventilatory control.
Presentation of new experimental data (details not specified in the abstract).

Main Results:

Systemic or neural inflammation impairs chemoreflexes, which are vital for regulating breathing.
Inflammation negatively affects respiratory motor plasticity, hindering the nervous system's ability to adapt motor output.

Conclusions:

Inflammation significantly undermines key aspects of ventilatory control, specifically chemoreflexes and respiratory motor plasticity.
Understanding these inflammatory mechanisms is fundamental for developing therapies for breathing disorders and enhancing compensatory responses in disease states.