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Updated: May 8, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Contact dermatitis induced by glatiramer acetate.

S Haltmeier¹, M Yildiz, S Müller

¹Department of Dermatology and Allergy, Cantonal Hospital of St Gallen, Switzerland. susannehaltmeier@gmx.net

Multiple Sclerosis (Houndmills, Basingstoke, England)

|July 7, 2011

Summary

Glatiramer acetate injections can cause contact dermatitis, a rare side effect. This case study highlights a positive lymphocyte transformation test confirming the allergy, leading to drug cessation and topical steroid treatment.

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Area of Science:

Immunology
Dermatology
Neurology

Background:

Glatiramer acetate is an immunomodulatory therapy for relapsing-remitting multiple sclerosis.
It is generally considered safe with a mild side effect profile.

Observation:

A 39-year-old woman developed contact dermatitis after two months of glatiramer acetate injections.
The patient experienced a severe skin reaction necessitating drug discontinuation.

Findings:

Diagnostic tests, including prick/scratch testing, were negative.
A lymphocyte transformation test showed a strong positive reaction to glatiramer acetate, confirming causality.
This represents the first reported case of glatiramer acetate-induced contact dermatitis.

Implications:

Contact dermatitis is a potential, albeit rare, adverse reaction to glatiramer acetate.
Accurate diagnosis requires specific immunological testing like the lymphocyte transformation test.
Management involves drug withdrawal and symptomatic treatment with topical corticosteroids.