Related Experiment Video
Updated: May 31, 2026

A Catheter-Related Candida albicans Infection Model in Mouse
Published on: March 22, 2024
Antimicrobial activity of B-Lock against bacterial and Candida spp. causing catheter-related bloodstream infections
M A Ghannoum1, N Isham, M R Jacobs
1Center for Medical Mycology, Department of Dermatology, University Hospitals Case Medical Center and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106-5028, USA. Mahmoud.Ghannoum@case.edu
Abstract:
The triple combination trimethoprim, EDTA, and ethanol (B-Lock), is an antimicrobial lock solution for use in indwelling intravascular catheters to prevent and treat catheter-associated infections. B-Lock demonstrated MICs of ≤0.05% (percentage of solution) against Candida spp. (n = 125) and 0.003% to 25% against bacterial strains (n = 175). B-Lock was also fungicidal against the majority of the Candida strains at 6% to 25%. B-Lock demonstrates potential value for the prevention and treatment of catheter-associated infections.
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