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Related Experiment Videos

Depression and antidepressant therapy: receptor dynamics.

F P Zemlan1, D L Garver

  • 1Department of Psychiatry, School of Medicine, University of Cincinnati, Ohio.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|January 1, 1990
PubMed
Summary
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New theories suggest depression involves altered serotonin (5-HT) and norepinephrine (NE) receptor subtype dynamics. Chronic antidepressant treatment positively impacts 5-HT1 receptor function and decreases beta-adrenergic and 5-HT2 receptor responsiveness.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Molecular Biology

Background:

  • Classical norepinephrine (NE) and serotonin (5-HT) theories of depression are outdated.
  • New theories focus on receptor subtype dynamics in depression and chronic antidepressant treatments.
  • Molecular genetics suggests reclassifying monoamine receptors based on structural homologies.

Purpose of the Study:

  • To investigate the role of serotonin (5-HT) and norepinephrine (NE) receptor subtypes in depression.
  • To explore the effects of chronic antidepressant treatment on these receptor systems.
  • To inform novel antidepressant drug development.

Main Methods:

  • Electrophysiologic studies in rats.
  • Preclinical behavioral models.

Related Experiment Videos

  • Patient neuroendocrine studies.
  • Receptor binding and cyclic AMP studies.
  • 5-HT2 receptor coupled PI turnover studies.

    • Main Results:

    • Chronic antidepressant treatment facilitates 5-HT1 receptor function and responsiveness in depressed patients.
    • Depression is linked to decreased central 5-HT1 receptor transmission.
    • Chronic antidepressant treatment decreases responsiveness of central beta-adrenergic (especially beta-1) receptors.
    • Chronic antidepressant treatment decreases 5-HT2 receptor number and function.

    Conclusions:

    • Some depression forms are linked to decreased 5-HT1 receptor responsiveness, reversed by chronic treatment.
    • Novel antidepressant development can target beta-1 agonists to decrease receptor responsiveness.
    • 5-HT2 receptors may be involved in specific depression types and their treatment.