Facile synthesis of polymer-enveloped ultrasmall superparamagnetic iron oxide for magnetic resonance imaging

Ultrasmall superparamagnetic iron oxide (USPIO) with synthetic polymer, based on magnetite core, was synthesized via facile photochemical in situ polymerization. A possible mechanism of photochemical in situ polymerization was proposed. The obtained polymer-enveloped UPSIO was characterized by transmission electron microscopy (TEM), photo-correlation spectroscopy (PCS), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric (TG) analysis and vibrating sampling magnetometer (VSM) measurement. Properties such as ultrasmall particle size, hydrophilicity, strong magnetization and surface characteristics, which are desirable for magnetic resonance imaging (MRI) contrast agents, were evaluated in detail. The resultant USPIO-based MRI contrast agent holds considerable promise in molecular MR tracking, MR immune imaging, cell tracking and targeted intracellular hyperthermia, etc.