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Updated: May 31, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
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Cisplatin ototoxicity affecting cochlear implant benefit.

Michael S Harris1, Jaimie L Gilbert, Kelly A Lormore

  • 1DeVault Otologic Research Laboratory, Department of Otolaryngology-Head and Neck Surgery, Indiana, USA. michharr@iupui.edu

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [And] European Academy of Otology and Neurotology
|July 7, 2011
PubMed
Summary

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Cisplatin chemotherapy can diminish cochlear implant benefits by affecting auditory nerve cells. This case highlights potential cochleotoxicity beyond the outer hair cells, impacting hearing aid effectiveness.

Area of Science:

  • Ototoxicity research
  • Neuroscience of hearing
  • Cancer treatment side effects

Background:

  • Cisplatin is a common chemotherapy agent used for osteosarcoma.
  • Cochlear implants (CIs) restore hearing in individuals with severe to profound hearing loss.
  • Cisplatin-induced ototoxicity is a known concern, primarily affecting outer hair cells.

Observation:

  • A single case study of an osteosarcoma patient treated with cisplatin.
  • The patient experienced a loss of benefit from their cochlear implant post-chemotherapy.
  • Increased cochlear implant programming levels (T- and C-levels) were required after cisplatin therapy.

Findings:

  • Cisplatin therapy led to a decline in cochlear implant effectiveness.
  • The patient's hearing sensitivity worsened despite having non-functioning outer hair cells.

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Last Updated: May 31, 2026

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  • This suggests cisplatin affects auditory structures beyond the outer hair cells, likely the spiral ganglion cells.

    • Implications:

    • Cisplatin-induced cochleotoxicity may target spiral ganglion cells, impacting neural auditory processing.
    • This finding has implications for managing hearing in cancer patients undergoing cisplatin treatment.
    • Further research is needed to understand the precise mechanisms and extent of cisplatin's neurotoxic effects on the auditory pathway.