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Updated: May 31, 2026

The In ovo CAM-assay as a Xenograft Model for Sarcoma

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

Disseminated hemangiosarcoma in a cow.

Matthew L Stock¹, Billy I Smith, Julie B Engiles

¹Department of Clinical Studies, University of Pennsylvania School of Veterinary Medicine, New Bolton Center, Pennsylvania 19348, USA. mstock@vet.upenn.edu

The Canadian Veterinary Journal = La Revue Veterinaire Canadienne

|July 7, 2011

Summary

This summary is machine-generated.

This study reports the first case of disseminated hemangiosarcoma in a cow, affecting the liver and spleen. The diagnosis was made antemortem in a cow presenting with lethargy and weight loss.

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Area of Science:

Veterinary Pathology
Bovine Medicine
Veterinary Oncology

Background:

Hemangiosarcoma is a malignant vascular tumor rarely reported in cattle.
Disseminated forms are even less common, posing diagnostic challenges.

Observation:

A 9-year-old cow presented with non-specific clinical signs including lethargy, weight loss, regenerative anemia, thrombocytopenia, and elevated liver enzymes.
Diagnostic imaging and clinical pathology findings suggested extensive hepatic and splenic involvement.

Findings:

Antemortem diagnosis of disseminated hemangiosarcoma was achieved.
This case represents the first report of hemangiosarcoma in a cow with a suspected primary origin in the liver and/or spleen.

Implications:

This case highlights the importance of considering hemangiosarcoma in cattle presenting with compatible clinical and clinicopathological signs.
Further research is warranted to understand the pathogenesis and incidence of hemangiosarcoma in cattle.