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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

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Related Experiment Video

Updated: May 31, 2026

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design
07:40

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design

Published on: May 31, 2021

Ageing and its implications.

P Jayanthi1, Elizabeth Joshua, K Ranganathan

  • 1Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Chennai, India.

Journal of Oral and Maxillofacial Pathology : JOMFP
|July 7, 2011
PubMed
Summary
This summary is machine-generated.

Ageing increases susceptibility to death due to complex genetic and environmental factors. This review explores various ageing theories and their roles in lifespan determination.

Keywords:
Ageingprogeroidtelomerasetelomeretheories

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Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
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Last Updated: May 31, 2026

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design
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Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
11:57

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Area of Science:

  • Gerontology
  • Biology
  • Genetics

Background:

  • Ageing is a natural process increasing vulnerability to mortality.
  • It's a complex, multifactorial phenomenon involving interactions at multiple organizational levels.
  • Individual and species longevity varies due to genetic and environmental influences.

Purpose of the Study:

  • To review the multifaceted nature of ageing processes.
  • To discuss the various theories explaining ageing.
  • To explore the roles of genetic and environmental factors in lifespan.

Main Methods:

  • Literature review of ageing theories.
  • Analysis of factors influencing ageing phenotype and longevity.
  • Discussion of multi-factorial interactions in ageing.

Main Results:

  • Ageing involves complex interactions of genetic and environmental factors.
  • Heterogeneity in ageing phenotypes and lifespan is observed.
  • Multiple theories attempt to explain the mechanisms of ageing.

Conclusions:

  • Ageing is a complex, multifactorial process.
  • Genetic and environmental factors significantly impact lifespan.
  • Understanding ageing theories is crucial for gerontological research.