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Cytomegalovirus in a macerated second trimester fetus: persistent viral inclusions on light and electron microscopy
D A Schwartz1, B Walker, B Furlong
1Department of Pathology, Emory University School of Medicine, Atlanta, Ga.
Abstract:
The macerated stillborn fetus represents at least one third of all perinatal deaths. Microscopic examination of these specimens is often unrewarding. We have reported a clinically unsuspected cytomegalovirus infection in a second trimester macerated fetus. Cells suggestive of CMV inclusions were identified by light microscopy, but electron microscopy confirmed the presence of viral infection and proved valuable in making the diagnosis even though necrosis was severe.
Insights
Cytomegalovirus infection can cause macerated stillborn fetuses, a common cause of perinatal death. Electron microscopy is crucial for diagnosing this viral infection, even with severe tissue damage.
Area of Science:
- Perinatology
- Virology
- Pathology
Background:
- Macerated stillborn fetuses constitute a significant portion of perinatal deaths.
- Microscopic examination of macerated fetuses is frequently inconclusive.
- Cytomegalovirus (CMV) is a potential, though often unsuspected, cause of fetal demise.