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17-α-Hydroxylase deficiency: An unusual case with primary amenorrhea and hypertension
Sunil Kumar Kota1, Kirtikumar Modi, Ratan Jha
1Department of Endocrinology, Medwin Hospital, Hyderabad, Andhra Pradesh, India.
Abstract:
A 14-year-old girl presented with acute onset quadriparesis and newly detected hypertension. Parental consanguinity, delayed puberty with normal stature form the additional information. Hypokalemia with metabolic alkalosis, low cortisol, high ACTH and FSH pointed to the possibility of CAH with 17α hydroxylase deficiency. 46XX karyotype and high progesterone supported this. Normalization of hypokalemia and hypertension with glucocorticoid treatment confirmed the diagnosis. In summary, the possibility of 17 OHD should be suspected in patients with hypokalemic myopathy, Hypertension and hypogonadism so that appropriate therapy can be implemented.
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