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Related Concept Videos

Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
The Menstrual Cycle01:19

The Menstrual Cycle

The menstrual cycle is a recurrent sequence of changes in the uterine endometrium, specifically its functional layer, the stratum functionalis. This cycle prepares the uterus for potential pregnancy. This cycle typically spans 21–35 days, averaging 28 days, and aligns with the ovarian cycle, regulated by fluctuating levels of ovarian hormones, primarily estrogen and progesterone.
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a uterine...
Menses Phase01:18

Menses Phase

The uterine cycle begins with the menstrual phase, which is considered day one of the cycle and typically lasts about five days. This phase is characterized by the degeneration and shedding of the stratum functionalis, the functional layer of the endometrium.
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
Proliferative Phase01:20

Proliferative Phase

The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

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Related Experiment Video

Updated: May 31, 2026

Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery
07:28

Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery

Published on: February 3, 2026

PURLs: consider this option for heavy menstrual bleeding.

Robert Levy1, Shailendra Prasad, Kate Rowland

  • 1North Memorial Family Medicine Residency, University of Minnesota, Minneapolis, USA.

The Journal of Family Practice
|July 7, 2011
PubMed
Summary

Heavy menstrual bleeding can now be treated with a new option for women unresponsive or intolerant to existing therapies. This provides an alternative choice for managing heavy periods.

Related Experiment Videos

Last Updated: May 31, 2026

Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery
07:28

Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery

Published on: February 3, 2026

Area of Science:

  • Gynecology
  • Reproductive Medicine

Background:

  • Heavy menstrual blood loss (HMB) significantly impacts women's quality of life.
  • Current treatment options for HMB include hormonal therapies, surgical interventions, and medical management.
  • Some women do not respond to or cannot tolerate existing HMB treatments.

Observation:

  • A novel treatment option has become available for women experiencing HMB.
  • This new choice is for individuals who have not found success with or cannot tolerate conventional HMB therapies.

Findings:

  • The introduction of a new therapeutic choice for managing heavy menstrual bleeding.
  • This addresses an unmet need for women with refractory or intolerant HMB.

Implications:

  • Expanded treatment possibilities for women suffering from heavy menstrual blood loss.
  • Potential improvement in patient outcomes and satisfaction for a challenging gynecological condition.