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Updated: May 31, 2026
![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions
Published on: March 20, 2014
SCS-pincer palladium-catalyzed auto-tandem catalysis using dendritic catalysts in semi-permeable compartments
Niels J M Pijnenburg1, Harm P Dijkstra, Gerard van Koten
1Organic Chemistry & Catalysis, Debye Institute for Nanomaterials Science, Utrecht University, Universiteitsweg 99, 3584, CG Utrecht, The Netherlands.
Abstract:
Novel monometallic and dendritic SCS-pincer palladium complexes 2, 3 and 4 have been synthesized in good yields (60-89%) and high purity (palladium loading >97%). These complexes were successfully used as catalysts in the stannylation of cinnamyl chloride with hexamethylditin and in the catalytic auto-tandem reaction consisting of this stannylation followed by an electrophilic addition with 4-nitrobenzaldehyde, showing similar reaction rates and selectivities for all complexes. Dendritic complex 4 has furthermore been used in the compartmentalized catalysis of single and auto-tandem reactions, allowing catalyst reuse for four consecutive runs.
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