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Related Experiment Video

Updated: May 31, 2026

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

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Hypersexual features in Huntington's disease.

A Jhanjee¹, K S Anand, B K Bajaj

¹Department of Psychiatry and Drug De-addiction, Lady Hardinge Medical College, Shaheed Bhagat Singh Marg, New Delhi 110001, India. Anurag_99@hotmail.com

Singapore Medical Journal

|July 7, 2011

Summary

This case study highlights a rare instance of early-onset Huntington's disease (HD) presenting with hypersexuality in a young woman. Treatment with olanzapine and haloperidol showed significant improvement in her symptoms.

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Area of Science:

Neuroscience
Neurology
Psychiatry

Background:

Huntington's disease (HD) is a progressive neurodegenerative disorder.
Sexual dysfunction is an underreported symptom in HD patients.
The etiology of sexual dysfunction in HD remains unclear, potentially involving brain lesions or psychosocial factors.

Observation:

A 30-year-old woman presented with early adulthood Huntington's disease.
Her presentation included hypersexuality, a rare manifestation.
The patient's quality of life was significantly impacted by this symptom.

Findings:

No established treatment guidelines exist for hypersexuality in Huntington's disease.
The patient received treatment with olanzapine and haloperidol.
Both medications led to a significant reduction in hypersexual behavior.

Implications:

This case suggests that atypical antipsychotics may be effective in managing hypersexuality in HD.
Further research is warranted to explore the neurobiological underpinnings of sexual dysfunction in HD.
This case contributes to understanding the diverse clinical spectrum of Huntington's disease.