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Serum fructosamine and retinopathy of prematurity

Senol Bozdag1, Serife Suna Oguz, Tulin Gokmen

  • 1Department of Neonatology, Zekai Tahir Burak Maternity and Teaching Hospital, Ankara, Turkey. senolbozdag@hotmail.com

Indian Journal of Pediatrics
|July 7, 2011
PubMed

Insights

Serum fructosamine does not predict retinopathy of prematurity in very low birth weight infants. However, the duration of hyperglycemia is linked to the development of this condition in premature infants.

Area of Science:

  • Neonatal Medicine
  • Ophthalmology
  • Endocrinology

Background:

  • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
  • Hyperglycemia is a common complication in very low birth weight (VLBW) infants and has been implicated in ROP development.
  • Serum fructosamine is a marker of glycemic control over the preceding 2-3 weeks.

Purpose of the Study:

  • To evaluate the predictive value of serum fructosamine for ROP development in VLBW infants.
  • To investigate the association between hyperglycemia duration and ROP in this population.

Main Methods:

  • A cohort of 167 premature infants (birth weight < 1500g, gestational age < 32 weeks) was studied.
  • Serum fructosamine levels were measured at birth and one month postnatally.
  • Hyperglycemia was defined as mean blood glucose > 150 mg/dL, and ROP was assessed by ophthalmologists.

Main Results:

  • Serum fructosamine levels did not differ significantly between infants who developed ROP and those who did not.
  • The duration of hyperglycemia was significantly longer in infants who developed ROP (3.05 days vs 1.69 days).
  • Multivariate analysis showed a significant correlation between hyperglycemia duration and ROP development (OR 3.26, p=0.035).

Conclusions:

  • Serum corrected fructosamine is not a reliable predictor of ROP in VLBW infants.
  • The duration of hyperglycemia, rather than fructosamine levels, appears to be a contributing factor to ROP development in this vulnerable group.
Abstract

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