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Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Gamma knife radiosurgery for cranial neurocytomas
Ali Genc1, Suheyla Uyar Bozkurt, Pinar Karabagli
1Department of Neurosurgery, Medical Faculty, Marmara University, Istanbul, Turkey.
Journal of Neuro-Oncology
|July 7, 2011
Summary
Gamma Knife Surgery (GKS) offers a safe and effective treatment for residual or recurrent neurocytomas. This study found GKS effectively reduced tumor volume in most patients without complications.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Central neurocytomas are rare tumors.
- Recurrent or residual neurocytomas pose treatment challenges.
- Conventional radiotherapy may have significant side effects.
Purpose of the Study:
- To evaluate the efficacy and safety of Gamma Knife Surgery (GKS) for treating residual or recurrent neurocytomas.
- To assess tumor response based on volume changes and histopathological findings.
Main Methods:
- Retrospective analysis of 22 patients with histologically confirmed neurocytomas treated with GKS.
- Tumor volume assessment using post-gadolinium MRI.
- Proliferative potential evaluated using MIB-1 labeling index.
Main Results:
- 15 out of 22 patients showed marked reduction in tumor volume after GKS.
- Tumor shrinkage increased with longer follow-up periods.
- No complications related to GKS were reported.
Conclusions:
- GKS is a safe and effective treatment option for residual or recurrent neurocytomas.
- Tumor response to GKS appears independent of the MIB-1 labeling index.
- Larger studies are needed to confirm these findings.
