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Updated: May 31, 2026

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
Published on: May 16, 2021
Fragment-based lead discovery: challenges and opportunities
Chaohong Sun1, Andrew M Petros, Philip J Hajduk
1Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, IL 60064-3500, USA.
Abstract:
Fragment-based lead discovery has undergone remarkable changes over the last 15 years. During this time, the pharmaceutical industry has changed dramatically as well, and continued evolution of the industry is assured. These changes present many challenges but also several opportunities for executing fragment-based drug design. This article will explore some of the more significant changes in the industry and how they may affect future discovery efforts related to fragment-based initiatives.

