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Riboswitches01:56

Riboswitches

Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...

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Related Experiment Video

Updated: May 31, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Remote communication in a DNA-based nanoswitch.

Célia Fonseca Guerra1, Zsolt Szekeres, F Matthias Bickelhaupt

  • 1Department of Theoretical Chemistry and Amsterdam Center for Multiscale Modeling, VU University Amsterdam, Amsterdam, The Netherlands. C.FonsecaGuerra@vu.nl

Chemistry (Weinheim an Der Bergstrasse, Germany)
|July 7, 2011
PubMed
Summary

Scientists remotely controlled DNA base pair hydrogen bonds using an organic wire. This "nano-telegraph" allows switching bonds between weak, intermediate, and strong states over nanometers.

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Area of Science:

  • Quantum Chemistry
  • Molecular Biology
  • Nanotechnology

Background:

  • Hydrogen bonds are crucial for DNA base pairing and stability.
  • Controlling these bonds remotely could enable novel molecular devices.

Purpose of the Study:

  • To investigate the remote switching of DNA base pair hydrogen-bond strength.
  • To explore the use of π-conjugated organic wires for remote molecular control.

Main Methods:

  • Quantum chemical calculations were employed.
  • Simulations modeled interactions between DNA base pairs and organic wires.

Main Results:

  • Demonstrated remote switching of hydrogen-bond strength across several nanometers.
  • Achieved control over three distinct states: weak, intermediate, and strong.
  • Verified the role of the π-conjugated organic wire as a molecular conduit.

Conclusions:

  • The π-conjugated organic wire acts as a functional nano-telegraph for DNA base pairing.
  • Remote, multi-state control of hydrogen bonds is feasible.
  • Opens possibilities for nanoscale molecular switches and sensors.