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Published on: December 19, 2014
In vitro evaluation of hexagonal polymeric micelles in macrophage phagocytosis
Hsieh-Chih Tsai1, Che-Hau Chang, Yie-Chan Chiu
1Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, Taiwan, ROC. h.c.tsai@mail.ntust.edu.tw
Abstract:
This paper develops a non-spherical polymeric micelle using an amphiphilic block copolymer and a porphyrin crystalline structure. The nanoscale polymer micelles were characterized by transmission electron microscopy (TEM) and atomic force microscopy (AFM), revealing particle sizes of approximately 150 nm with a particular shape in the hexagonal lattice. The shape shows the selective uptake efficacy for the HeLa and macrophage cells, and inhibits phagocytosis against the macrophage.
