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Related Experiment Video

Updated: May 31, 2026

Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters
09:43

Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters

Published on: August 22, 2014

Sombrero-shaped plasmonic nanoparticles with molecular-level sensitivity and multifunctionality.

Jung-Sub Wi1, Edward S Barnard, Robert J Wilson

  • 1Department of Materials Science and Engineering, Stanford University, Stanford, California 94305, USA.

ACS Nano
|July 8, 2011
PubMed
Summary

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We developed new plasmonic nanoparticles with internal Raman hot spots for enhanced molecular detection. This fabrication method improves detection sensitivity by 1000-fold, enabling single-molecule detection.

Area of Science:

  • Nanotechnology
  • Materials Science
  • Spectroscopy

Background:

  • Plasmonic nanoparticles offer unique optical properties for sensing.
  • Developing highly sensitive molecular detection methods is crucial for diagnostics and research.
  • Engineered nanostructures can enhance signal amplification in spectroscopic techniques.

Purpose of the Study:

  • To demonstrate a top-down synthesis of monodisperse plasmonic nanoparticles with internal Raman hot spots.
  • To achieve a significant improvement in molecular detection levels using these engineered nanoparticles.
  • To explore the potential of these nanoparticles for molecular imaging and detection applications.

Main Methods:

  • Fabrication of Raman-active nanoparticles using nanoimprint lithography and thin-film deposition.

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Last Updated: May 31, 2026

Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters
09:43

Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters

Published on: August 22, 2014

Multifunctional Hybrid Fe2O3-Au Nanoparticles for Efficient Plasmonic Heating
08:04

Multifunctional Hybrid Fe2O3-Au Nanoparticles for Efficient Plasmonic Heating

Published on: February 20, 2016

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
09:13

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

  • Design of internal nanoparticle structures featuring a silver core, a silicon dioxide base, and a sub-10 nm gap.
  • Characterization using confocal Raman spectroscopy and electromagnetic simulations.

    • Main Results:

    • Successful synthesis of monodisperse plasmonic nanoparticles with internal Raman hot spots.
    • Identification of hot spots at the nanoparticle's inner perimeter, leading to signal enhancement.
    • Achieved a 1000-fold improvement in minimum molecular detection level, enabling detection of few molecules.

    Conclusions:

    • Direct fabrication offers a pathway to create exotic monodisperse nanoparticles with engineered internal nanostructures.
    • These nanoparticles demonstrate significant potential for highly sensitive molecular imaging and detection.
    • A multimodality version incorporating magnetic properties was also successfully demonstrated.