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Mouse strain differences in phencyclidine-induced behavioural changes.

Akihiro Mouri1, Takenao Koseki, Shiho Narusawa

  • 1Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.

The International Journal of Neuropsychopharmacology
|July 8, 2011
PubMed
Summary
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Phencyclidine (PCP) affects mouse behavior differently across strains, impacting psychosis models. Understanding these strain differences is crucial for comparing genetic and drug-induced models of mental illness.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Animal Models

Background:

  • Phencyclidine (PCP) administration models psychosis in animals.
  • Genetic factors for schizophrenia and bipolar disorder are being identified, leading to genetic animal models.
  • Comparing drug-induced and genetic models is vital for understanding multifactorial mental illnesses.

Purpose of the Study:

  • To systematically compare behavioral changes induced by PCP across different mouse strains.
  • To address the technical gap in comparing PCP models (often non-C57BL/6) with genetic models (typically C57BL/6).

Main Methods:

  • Administered PCP to C57BL/6N, C57BL/6J, ddY, and ICR mouse strains.
  • Assessed behavioral changes including hyperlocomotion and forced swim test immobility.

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  • Evaluated recognition memory using the novel object recognition test after chronic PCP withdrawal.

    • Main Results:

    • Significant strain differences were observed in PCP-induced hyperlocomotion and forced swim test immobility (ddY > C57BL/6N/J > ICR).
    • No strain differences were found in the impairment of recognition memory following chronic PCP administration.
    • These findings highlight strain-specific responses to PCP in behavioral assays.

    Conclusions:

    • Provides guidance for comparing genetic and PCP-induced psychosis models in C57BL/6 mice.
    • Strain differences in PCP response may offer insights into biological mechanisms of endophenotypes relevant to mental illness.