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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Related Experiment Video

Updated: May 31, 2026

Isolation of Umbilical Cord-Derived Mesenchymal Stem Cells with High Yields and Low Damage
04:47

Isolation of Umbilical Cord-Derived Mesenchymal Stem Cells with High Yields and Low Damage

Published on: July 5, 2024

Wharton's Jelly stem cells: future clinical applications.

R R Taghizadeh1, K J Cetrulo, C L Cetrulo

  • 1AuxoCell Laboratories, Inc., 245 First Street, Cambridge, MA 02142, USA.

Placenta
|July 8, 2011
PubMed
Summary

Wharton

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Perinatal Stem Cells

Background:

  • The human umbilical cord's Wharton's Jelly harbors a potent stem cell population.
  • These cells represent a distinct subset, termed perinatal stem cells.
  • Their therapeutic potential is increasingly recognized.

Purpose of the Study:

  • To review the therapeutic potential of Wharton's Jelly derived stem cells.
  • To define and compare perinatal stem cells to other stem cell sources.
  • To discuss cryopreservation for future cell-based therapies.

Main Methods:

  • Literature review of existing research on Wharton's Jelly stem cells.
  • Comparison of perinatal stem cells with other stem cell types.
  • Analysis of pre-clinical and clinical trial data for mesenchymal stem cells.

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Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow
09:03

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

Published on: March 17, 2023

Related Experiment Videos

Last Updated: May 31, 2026

Isolation of Umbilical Cord-Derived Mesenchymal Stem Cells with High Yields and Low Damage
04:47

Isolation of Umbilical Cord-Derived Mesenchymal Stem Cells with High Yields and Low Damage

Published on: July 5, 2024

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow
09:03

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

Published on: March 17, 2023

Main Results:

  • Wharton's Jelly contains a unique and potent stem cell population.
  • Perinatal stem cells exhibit characteristics suitable for regenerative medicine.
  • Cryopreservation methods are viable for preserving therapeutic potential.
  • Evidence supports the application of these cells in various therapeutic contexts.

Conclusions:

  • Wharton's Jelly stem cells, or perinatal stem cells, offer significant therapeutic promise.
  • Their unique properties and potential for cryopreservation support regenerative medicine applications.
  • Further research into their clinical applications is warranted.