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Hematologic parameters and angiographic progression of coronary atherosclerosis

Nihat Kalay1, Orhan Dogdu, Fatih Koc

  • 1Department of Cardiology, Erciyes University Medical Faculty, Kayseri, Turkey. nihatkalay@hotmail.com

Angiology
|July 8, 2011
PubMed

Insights

The neutrophil/lymphocyte (N/L) ratio, a blood test marker, predicts atherosclerosis progression in cardiovascular disease patients. A higher N/L ratio indicates a greater risk of disease advancement.

Area of Science:

  • Cardiology
  • Hematology
  • Pathophysiology

Background:

  • Hematologic parameters are crucial for cardiovascular disease prognosis.
  • The link between atherosclerosis progression and hematologic markers requires further definition.

Purpose of the Study:

  • To investigate the relationship between hematologic parameters, specifically mean platelet volume (MPV) and neutrophil/lymphocyte (N/L) ratio, and the progression of atherosclerosis.
  • To identify predictors of atherosclerosis progression in patients undergoing repeat coronary angiography.

Main Methods:

  • A cohort of 394 patients requiring repeat coronary angiography was analyzed.
  • Patients were categorized into progressive (n=196) and non-progressive (n=198) atherosclerosis groups based on angiography results.
  • Hematologic parameters (MPV, N/L ratio), glucose, creatinine, and cholesterol levels were measured.

Main Results:

  • The progressive atherosclerosis group exhibited significantly higher glucose, creatinine, and cholesterol levels.
  • Mean platelet volume (MPV) was similar between groups.
  • The neutrophil/lymphocyte (N/L) ratio was significantly elevated in the progressive group (5.0 ± 5.1 vs 3.2 ± 3; P = .001).
  • Multivariate analysis confirmed the N/L ratio as a significant predictor of atherosclerosis progression (RR: 2.267, P = .03).
  • Patients with a high N/L ratio showed a higher progression rate (56% vs 39%).

Conclusions:

  • The neutrophil/lymphocyte (N/L) ratio is a significant and independent predictor of atherosclerosis progression.
  • Elevated N/L ratio may serve as a valuable biomarker for identifying patients at higher risk of cardiovascular disease advancement.

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