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Related Concept Videos

Test Cross01:39

Test Cross

Alleles are different forms of the same gene. Humans and other diploid organisms inherit two alleles of every gene, one from each parent.
Test Cross01:39

Test Cross

Alleles are different forms of the same gene. Humans and other diploid organisms inherit two alleles of every gene, one from each parent.
Monohybrid Crosses01:20

Monohybrid Crosses

Overview
Monohybrid Crosses01:20

Monohybrid Crosses

Overview
Dihybrid Crosses01:18

Dihybrid Crosses

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Dihybrid Crosses01:18

Dihybrid Crosses

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Genetic analysis in the Collaborative Cross breeding population.

Vivek M Philip1, Greta Sokoloff, Cheryl L Ackert-Bicknell

  • 1Systems Genetics Group, Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA.

Genome Research
|July 8, 2011
PubMed
Summary
This summary is machine-generated.

The Collaborative Cross (CC) mouse population offers high genetic diversity for studying complex diseases. Despite some inbreeding effects, it provides superior phenotypic variation and precise genetic mapping capabilities.

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Area of Science:

  • Genetics
  • Systems Biology
  • Animal Models

Background:

  • Genetic reference populations are crucial for understanding disease-related phenotypes.
  • Existing mouse models have limitations in allelic diversity and may exhibit inbreeding depression.
  • The Collaborative Cross (CC) was developed to address these limitations.

Purpose of the Study:

  • To characterize the allelic and phenotypic diversity of the partially inbred Collaborative Cross (CC) mouse population.
  • To assess the impact of inbreeding depression on diversity within the CC population.
  • To evaluate the CC population's potential for genetic mapping and disease research.

Main Methods:

  • Utilized a randomized breeding design involving eight founder strains (five common laboratory, three wild-derived).
  • Systematically outcrossed founder strains followed by inbreeding to create new recombinant inbred strains.
  • Characterized physiological, morphological, and behavioral traits in the partially inbred CC population.

Main Results:

  • Phenotypic variation in the CC population surpasses existing mouse genetic reference populations.
  • High founder genetic diversity and novel epistatic combinations contribute to increased variation.
  • Evidence of allele purging was observed, but high diversity and mapping precision are maintained.

Conclusions:

  • The Collaborative Cross (CC) mouse population demonstrates significant potential for systems genetic analysis.
  • Its high allelic and phenotypic diversity offers advantages over existing models.
  • Findings have implications for the development of future genetic reference populations.