Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Food Intake

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

Pyloric Obstruction

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...

Peptic Ulcer Disease V: Surgical Management and Nursing Care

Peptic Ulcer Disease V: Surgical Management and Nursing Care

Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...

Glucagon-like Receptor Agonists

Glucagon-like Receptor Agonists

Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Limited validity of an AI-powered app for dietary assessment in females with obesity.

NPJ digital medicine·2026

Same author

Transection of the glossopharyngeal nerve reduces energy and sugar intake but does not affect fat intake or meal patterns in rats offered a palatable cafeteria diet.

Physiology & behavior·2026

Same author

Gustatory and olfactory-guided responsiveness to maltodextrin solutions in mice.

American journal of physiology. Regulatory, integrative and comparative physiology·2025

Same author

Health Benefits Beyond the Scale: The Role of Diet and Nutrition During Weight Loss Programmes.

Nutrients·2024

Same author

Oxyntomodulin physiology and its therapeutic development in obesity and associated complications.

The Journal of physiology·2024

Same author

Survodutide for treatment of obesity: rationale and design of two randomized phase 3 clinical trials (SYNCHRONIZE™-1 and -2).

Obesity (Silver Spring, Md.)·2024

Search research articles

Related Experiment Video

Updated: May 31, 2026

Roux-en-Y Gastric Bypass Operation in Rats

Roux-en-Y Gastric Bypass Operation in Rats

Published on: June 11, 2012

Gastric bypass reduces fat intake and preference.

Carel W le Roux¹, Marco Bueter, Nadine Theis

¹Dept. of Investigative Medicine, Hammersmith Hospital, Imperial College London, Du Cane Road, London W12 0NN, UK. c.leroux@imperial.ac.uk

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology

|July 8, 2011

Summary

Roux-en-Y gastric bypass significantly reduces fat intake and preference for high-fat foods in both rats and humans. This change in taste preference, potentially linked to GLP-1 and conditioned taste aversion, may contribute to sustained weight loss after surgery.

More Related Videos

One-anastomosis Gastric Bypass (OAGB) in Rats

One-anastomosis Gastric Bypass (OAGB) in Rats

Published on: November 10, 2018

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers

Published on: August 21, 2021

Related Experiment Videos

Last Updated: May 31, 2026

Roux-en-Y Gastric Bypass Operation in Rats

Roux-en-Y Gastric Bypass Operation in Rats

Published on: June 11, 2012

One-anastomosis Gastric Bypass (OAGB) in Rats

One-anastomosis Gastric Bypass (OAGB) in Rats

Published on: November 10, 2018

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers

Published on: August 21, 2021

Area of Science:

Bariatric Surgery
Obesity Research
Gastroenterology

Background:

Roux-en-Y gastric bypass (RYGB) is a highly effective treatment for morbid obesity.
Understanding the mechanisms behind RYGB's efficacy, particularly regarding dietary intake and preferences, is crucial.

Purpose of the Study:

To investigate the impact of RYGB on fat intake and preference in both rat models and human patients.
To explore potential physiological mechanisms, such as GLP-1 levels and conditioned taste aversion, contributing to altered food preferences post-RYGB.

Main Methods:

Comparative analysis of dietary fat proportion in human patients 6 years post-RYGB versus vertical-banded gastroplasty.
Assessment of fat intake, caloric consumption, and preference for high-fat solutions (Intralipid) in rats following RYGB compared to sham controls.
Evaluation of appetitive and consummatory behaviors using brief access tests.
Measurement of glucagon-like peptide-1 (GLP-1) levels.
Induction of conditioned taste aversion using oral gavage of corn oil after saccharin ingestion in rats.

Main Results:

Human RYGB patients showed a significantly lower proportion of dietary fat 6 years after surgery compared to vertical-banded gastroplasty patients.
Rats undergoing RYGB exhibited reduced total fat and caloric intake, increased consumption of low-fat chow, and significantly lower preference for high Intralipid concentrations.
No differences in brief access tests for appetitive or consummatory behavior were observed between RYGB and sham rats.
GLP-1 levels were elevated post-RYGB in rats.
Oral corn oil administration induced conditioned taste aversion in RYGB rats.

Conclusions:

Altered fat preference, potentially mediated by postingestive effects leading to conditioned taste aversion, may play a significant role in the long-term weight loss achieved after RYGB.
The role of GLP-1 in mediating postprandial responses and contributing to these changes warrants further investigation.