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Updated: May 31, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
Development of newborn and infant vaccines
Guzman Sanchez-Schmitz1, Ofer Levy
1Children's Hospital Boston, Boston, MA 02115, USA. ofer.levy@childrens.harvard.edu
Abstract:
Vaccines for early-life immunization are a crucial biomedical intervention to reduce global morbidity and mortality, yet their developmental path has been largely ad hoc, empiric, and inconsistent. Immune responses of human newborns and infants are distinct and cannot be predicted from those of human adults or animal models. Therefore, understanding and modeling age-specific human immune responses will be vital to the rational design and development of safe and effective vaccines for newborns and infants.
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