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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

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Related Experiment Video

Updated: May 31, 2026

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

Epigenetics: principles and practice.

James P Hamilton1

  • 1Division of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. jpahamilton@jhmi.edu

Digestive Diseases (Basel, Switzerland)
|July 8, 2011
PubMed
Summary
This summary is machine-generated.

Epigenetics involves heritable gene expression changes without altering DNA sequence. These changes, influenced by lifestyle, are crucial for understanding and treating digestive diseases.

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Last Updated: May 31, 2026

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Published on: January 2, 2009

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

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A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies
08:04

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies

Published on: August 13, 2020

Area of Science:

  • Molecular Biology
  • Genetics
  • Gastroenterology

Background:

  • Epigenetics refers to heritable changes in gene expression not caused by DNA sequence alterations.
  • Key epigenetic mechanisms include DNA methylation, chromatin modifications, imprinting, and non-coding RNA.
  • Epigenetic regulation impacts long-term health, with diet and environment potentially influencing these patterns.

Purpose of the Study:

  • To explore the role of epigenetics in digestive diseases and gastrointestinal malignancies.
  • To highlight the potential of epigenetic modifications as biomarkers for cancer detection and treatment.
  • To discuss the therapeutic implications of reversing epigenetic changes.

Main Methods:

  • Review of existing literature on epigenetics in digestive diseases.
  • Analysis of studies linking lifestyle factors to epigenetic alterations and disease risk.
  • Examination of epigenetic modifications in cancer and precancerous lesions.

Main Results:

  • Aberrant epigenetic patterns are associated with digestive diseases like Barrett's esophagus, cirrhosis, and inflammatory bowel disease.
  • Epigenetic research in gastrointestinal and hepatobiliary diseases has yielded significant discoveries.
  • Epigenetic modifications in precancerous lesions show promise for early cancer detection and prognosis.

Conclusions:

  • Epigenetic modifications offer potential for novel biomarkers in early cancer detection, prediction, prognosis, and treatment response.
  • Reversing epigenetic changes presents a promising target for new therapeutic strategies and drug development.
  • Future medical practice is expected to integrate epigenetic mechanisms into diagnostics, treatments, and lifestyle recommendations.