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Updated: May 31, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
Published on: December 9, 2015
[Microsatellite instability and loss of heterozygosity in cancer]
Janina Didžiapetrienė1, Daiva Kanopienė, Konstantinas Povilas Valuckas
1Institute of Oncology, Vilnius University, Santariškių, Lithuania. janina.didziapetriene@vuoi.lt
Abstract:
Literature review on genetic alterations (microsatellite instability and loss of heterozygosity) in different types of cancer is presented. Microsatellite instability and loss of heterozigosity are significant processes in carcinogenesis. The evaluation of microsatellite instability in cancer patients might be of clinical importance as a prognostic and predictive factor. The most of up-to-date data available are on microsatellite instability in colorectal cancer. For other types of cancer, the number of publications on microsatellite instability is rapidly increasing.
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