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Related Concept Videos

Three Developmental Domains01:29

Three Developmental Domains

Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
Three-Domain System of Life01:21

Three-Domain System of Life

Ribosomal RNA (rRNA) sequence analysis revealed three distinct groups of cells: eukaryotes, bacteria, and archaea. In 1978, Carl R. Woese proposed the concept of domains, a taxonomic level above kingdoms, to differentiate these groups. He suggested that archaea and bacteria, despite their similar appearance, represent separate domains. Domains differ in rRNA, membrane lipid structure, transfer RNA, and antibiotic sensitivity.In this classification, animals, plants, and fungi belong to the...
Membrane Domains01:18

Membrane Domains

The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the anterior...
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
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Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Conservation of Protein Domains02:26

Conservation of Protein Domains

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...

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Related Experiment Video

Updated: May 31, 2026

Protocols for C-Brick DNA Standard Assembly Using Cpf1
12:03

Protocols for C-Brick DNA Standard Assembly Using Cpf1

Published on: June 15, 2017

BRCT domains: easy as one, two, three.

Charles Chung Yun Leung1, J N Mark Glover

  • 1Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.

Cell Cycle (Georgetown, Tex.)
|July 8, 2011
PubMed
Summary

BRCA1 C-terminal (BRCT) domains are key in DNA damage response signaling. Structural diversity enables these domains to perform various functions beyond phospho-peptide binding, including DNA and PAR binding.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Genetics

Background:

  • BRCA1 C-terminal (BRCT) domains are crucial signaling modules in the DNA damage response (DDR).
  • BRCT domains function not only in phospho-peptide binding but also in phosphorylation-independent protein, DNA, and poly(ADP-ribose) (PAR) binding.
  • The functional versatility of BRCT domains arises from diverse structural arrangements, including isolated single domains and higher-order homo- or hetero-domain complexes.

Purpose of the Study:

  • To review recent structural and biochemical findings on BRCT domains.
  • To elucidate how structural features contribute to the functional diversity of BRCT domains.
  • To highlight the multifaceted roles of BRCT domains in cellular signaling pathways.

Main Methods:

  • Literature review of structural and biochemical studies.

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  • Analysis of domain architecture and protein-protein interaction data.
  • Integration of data to correlate structure with function.

    • Main Results:

    • BRCT domains exhibit significant structural diversity, existing as monomers or in various complex assemblies.
    • Structural variations directly influence the binding capabilities of BRCT domains, including phospho-peptide, protein, DNA, and PAR interactions.
    • Both single and tandem BRCT domain arrangements display a wide range of functional activities.

    Conclusions:

    • The structural plasticity of BRCT domains underpins their diverse roles in the DNA damage response.
    • Understanding BRCT domain structure-function relationships is vital for deciphering complex cellular signaling.
    • Further research into BRCT domain complexes may reveal novel therapeutic targets for DDR-related diseases.