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Updated: May 31, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
Published on: August 21, 2017
Leber hereditary optic neuropathy mimicking neuromyelitis optica
Collin M McClelland1, Gregory P Van Stavern, Alex C Tselis
1Department of Ophthalmology, Washington University, St. Louis, Missouri, USA. mcclellandc@vision.wustl.edu
Abstract:
Leber hereditary optic neuropathy (LHON) is rarely associated with multiple sclerosis-like features. We present a case of a 65-year-old African American woman with LHON masquerading as neuromyelitis optica (NMO). We highlight the features of the clinical examination and MRI that were suggestive of an alternative diagnosis and review the literature regarding LHON and multiple sclerosis. The diagnosis of LHON should be considered in all cases of acute or subacute bilateral optic neuropathy, including presumed seronegative NMO.
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