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Related Experiment Video

Updated: May 31, 2026

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

Probiotics in hepatology.

Jan Lata¹, Jana Jurankova, Marcela Kopacova

¹Department of Internal Medicine, Faculty of Medicine and University Hospital, Ostrava University, 708 52 Ostrava-Poruba, Czech Republic. jan.lata@osu.cz

World Journal of Gastroenterology

|July 8, 2011

Summary

This summary is machine-generated.

This review explores how intestinal microflora impacts liver diseases. Probiotics show promise in managing complications of liver cirrhosis and potentially non-alcoholic steatohepatitis.

Keywords:

Intestinal microflora Liver cirrhosis Liver encephalopathy Non-alcoholic steatohepatitis Probiotics

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Last Updated: May 31, 2026

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

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Published on: July 31, 2019

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

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Published on: April 6, 2022

Area of Science:

Gastroenterology and Hepatology
Microbiology
Immunology

Background:

The intestinal microflora plays a crucial role in maintaining gut barrier function and immune homeostasis.
Alterations in gut microbiota, including bacterial overgrowth and translocation, are observed in liver cirrhosis.
These dysbiotic changes contribute to the pathogenesis of liver disease.

Purpose of the Study:

To review the role of intestinal microflora in liver diseases.
To discuss the current and potential applications of probiotics in hepatology.
To evaluate the impact of probiotics on gut barrier function and liver inflammation.

Main Methods:

Literature review of studies on intestinal microflora and liver diseases.
Analysis of research on probiotic efficacy in animal models and human clinical trials.
Examination of mechanisms by which probiotics influence gut permeability and bacterial translocation.

Main Results:

Probiotics can decrease intestinal permeability, bacterial translocation, and endotoxemia.
Clinical evidence supports probiotic use primarily for hepatic encephalopathy.
Probiotics may mitigate oxidative and inflammatory liver damage, suggesting potential for non-alcoholic steatohepatitis.

Conclusions:

Intestinal microflora dysbiosis is a significant factor in liver disease progression.
Probiotics demonstrate therapeutic potential in managing liver cirrhosis complications and infections post-liver transplantation.
Further research may establish probiotics as a viable treatment for non-alcoholic steatohepatitis.