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Synchronous bilateral neuroendocrine ductal carcinoma in situ
Hisae Honami1, Keiichi Sotome, Goi Sakamoto
1Department of Clinical Laboratory, Fussa Hospital, 1-6-1 Kamidaira, Fussa, Tokyo, 197-8511, Japan, kensa@fussahp.jp.
Breast Cancer (Tokyo, Japan)
|July 8, 2011
Summary
This study reports the first case of bilateral neuroendocrine ductal carcinoma in situ (NE-DCIS), a rare breast cancer variant. Diagnosis was confirmed through histopathology and immunohistochemistry in a 54-year-old woman.
Area of Science:
- Oncology
- Pathology
- Radiology
Background:
- Neuroendocrine ductal carcinoma in situ (NE-DCIS) is a rare breast malignancy.
- Distinguishing NE-DCIS from other ductal carcinoma in situ (DCIS) variants is crucial for accurate diagnosis and treatment.
- Bilateral breast involvement in NE-DCIS is exceptionally uncommon.
Observation:
- A 54-year-old premenopausal woman presented with hemorrhagic nipple discharge.
- Imaging revealed mass-like lesions in the left breast and non-mass-like lesions in the right breast.
- Core-needle biopsy and subsequent excisional biopsies confirmed bilateral NE-DCIS without invasive components.
Findings:
- Histopathological examination revealed bilateral breast lesions with similar characteristics, including solid growth of polygonal or spindle-shaped carcinoma cells within mammary ducts.
- Immunohistochemical staining confirmed the expression of neuroendocrine markers (chromogranin A and synaptophysin) in tumor cells from both breasts.
- This case represents the first documented instance of synchronous NE-DCIS in both breasts.
Implications:
- This case highlights the importance of thorough pathological evaluation and immunohistochemistry in diagnosing rare breast cancer variants like NE-DCIS.
- Synchronous bilateral NE-DCIS, though rare, should be considered in the differential diagnosis of breast lesions, especially in cases with suspicious imaging findings.
- Further research into the pathogenesis and clinical behavior of NE-DCIS is warranted.
